Quaid welcomed his youngest children, Thomas Boone Quaid and Zoe Grace Quaid, with his third wife, Kimberly Buffington, via gestational carrier on November 8, 2007, in Santa Monica. Thomas was born first at 8:26 a.m., weighing 6 lbs. 12 oz., followed by Zoe just two minutes later, who weighed 5 lbs. 9 oz. Shortly after their birth, the twins were hospitalized at Cedars-Sinai Medical Center in L.A. due to staph infections. A tragic error occurred when they were accidentally given 1,000 times the recommended dose of the blood thinner Heparin, putting them in critical condition. Quaid and Buffington only learned of the overdose the next morning, with Buffington later telling the *Los Angeles Times* that by the time they arrived at the hospital, both babies were “in incubators with cords attached to them.”Fortunately, by early December 2007, the twins had fully recovered and were discharged. Following this ordeal, Quaid established The Quaid Foundation to raise awareness about medical errors.Reflecting on the experience in March 2008, Quaid told * that it gave him a “greater appreciation of life in general.””It’s the greatest thing to hold those kids and see their faces because we had a happy ending,” he said. “It’s great to be a normal dad with the normal problems of not having enough hands for both of them.”He added, “If they hadn’t made it, it really would have changed my life. But they did survive. So it changed my attitude.”During a February 2008 press event for his film *Vantage Point*, Quaid discussed how fatherhood felt different the second time around. He noted that it was “a lot easier” now.”It’s easier in the sense that when the first one comes along you worry about everything. The second ones come along, ‘Oh, yeah, yeah, yeah, that’s fine, seen that, done that,'” he said. “You’re a little more relaxed about it. But with two, you need another arm.”Quaid also humorously shared how  often struggled to tell his then-3-month-old twins apart. “One’s wearing blue, the other one’s wearing pink,” he said, “but you’d still be surprised [with] , because they don’t want to make a mistake, they go, ‘Oh, that’s the … a girl, isn’t it?’ “Though Quaid generally keeps his family life private, he offered an update on the twins during a December 2015 appearance on the *Allegedly with Theo Von & Matthew Cole Weiss* podcast.”They’re perfectly normal as could be now,” he said. “They’re like the head of their class.”He continued, “But you know, it’s something that happens to you, you feel strongly about and you step up for it. It was really the kids that went through it and they were the ones that did it.””It was the most frightening time of our lives. But they came through it,” he concluded.